The distribution of CTL epitopes in HIV-1 appears to be random, and similar to that of other proteomes |
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Authors: | Boris V Schmid Can Keşmir Rob J de Boer |
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Affiliation: | (1) Theoretical Biology, Utrecht University, Utrecht, Utrecht, the Netherlands;(2) Academic Biomedical Centre, Utrecht University, the Netherlands |
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Abstract: | Background HIV-1 viruses are highly capable of mutating their proteins to escape the presentation of CTL epitopes in their current host. Upon transmission to another host, some escape mutations revert, but other remain stable in the virus sequence for at least several years. Depending on the rate of accumulation and reversion of escape mutations, HIV-1 could reach a high level of adaptation to the human population. Yusim et. al. hypothesized that the apparent clustering of CTL epitopes in the conserved regions of HIV-1 proteins could be an evolutionary signature left by large-scale adaptation of HIV-1 to its human/simian host. |
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