Quickening the pace: looking into the heart of HCN channels |
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| Authors: | Rosenbaum Tamara Gordon Sharona E |
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| Institution: | University of Washington, Department of Physiology and Biophysics, Box 357290, Seattle, WA 98195, USA. |
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| Abstract: | Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contribute to a wide range of physiological functions and regulate cardiac and neuronal pacemaker activity. Here, we review recent advances in three areas: the polarity of the S4 movement with hyperpolarization, the location of the activation gate, and the structure of the C-terminal C linker and CNBD. |
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