A model for cell type localization in the migrating slug of <Emphasis Type="Italic">Dictyostelium discoideum</Emphasis> based on differential chemotactic sensitivity to cAMP and differential sensitivity to suppression of chemotaxis by ammonia |
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Authors: | Ira N Feit Jeffrey Pawlikowski Caroline Zawilski |
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Institution: | (1) Franklin and Marshall College, Lancaster, PA 17603, USA |
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Abstract: | The three basic cell types in the migrating slug of Dictyostelium discoideum show differential chemotactic response to cyclic AMP (cAMP) and differential sensitivity to suppression of the chemotaxis
by ammonia. The values of these parameters indicate a progressive maturation of chemotactic properties during the transdifferentiation
of slug cell types. We present a model that explains the localization of the three cell types within the slug based on these
chemotactic differences and on the maturation of their chemotactic properties. |
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Keywords: | Ammonia chemotaxis cyclic AMP (cAMP) Dictyostelium discoideum |
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