Thiophene derivatives: a new series of potent norepinephrine and serotonin reuptake inhibitors |
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| Authors: | Zhang Ao Zhou Guochun Rong Suo-Bao Johnson Kenneth M Zhang Mei Kozikowski Alan P |
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| Affiliation: | Drug Discovery Program, Department of Neurology, Georgetown University Medical Center, 3900 Reservoir Road, NW, Washington, DC 20007-2197, USA. |
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| Abstract: | A series of (1S,3S,6R,10S)-(Z)-9-(thienylmethylene- or substituted thienylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes was prepared and evaluated for the ability to block dopamine, serotonin, and norepinephrine reuptake by their respective transporters. Compound 5b is a NET-selective inhibitor, 5c is a mixed NET- and SERT-selective inhibitor, while 11 is a SERT-selective inhibitor. |
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