Macromolecular desorientation in detached tendons

Conclusions Based on the results obtained on the grounds of the present discussion we may conclude: Under the described condition, in the detached tendons of guinea pigs and also in the implanted tendons the acid mucopolysaccharides gradually undergo a structural disorder, loosing its molecular orientation. In the referred tendons, the loss of structural orientation of the acid mucopolysaccharides proceeds the desorientation of the collagen polypeptide chains. In the tendon repair process, under the described conditions, acid mucopolysaccharides with oriented macromolecules are elaborated during the fibrillogenesis phenomenon.This paper is part of the author's Doctoral and Livre Docencia thesis published in October 1964.Professor do Departamento de Patologia da Faculdade de Farmácia e Odontologia de Piracicaba — Govêrno do Estado de São Paulo.