Rabies Group-Specific Ribonucleoprotein Antigen and a Test System for Grouping and Typing of Rhabdoviruses |
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| Authors: | L. G. Schneider B. Dietzschold R. E. Dierks W. Matthaeus P.-J. Enzmann K. Strohmaier |
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| Affiliation: | 1Federal Research Institute for Animal Virus Diseases, Tübingen, Postfach 1149, BRD, West Germany |
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| Abstract: | Cell-associated ribonucleoprotein (RNP) was isolated from BHK-21 cells infected with several strains of rabies and rabies-related viruses. The RNP-antigen from rabies and related viruses induced the formation of complement-fixing, precipitating, and immunofluorescent antibodies, and proved to be the group-specific antigen common to all rabies viruses. Antigens of the envelope which induce virus-neutralizing antibodies are apparently determinative for the serotype of a virus as evidenced by two-way neutralization tests. A combination of these methods seems to be a useful approach to the serological grouping and typing of rhabdoviruses. |
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