ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis |
| |
Authors: | Verma Priyanka Dalal Krishna |
| |
Institution: | Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India. |
| |
Abstract: | Osteoarthritis (OA) is a progressive disease of the joints characterized by degradation of articular cartilage. Although disease initiation may be multi-factorial, the cartilage destruction appears to be a result of uncontrolled proteolytic extracellular matrix destruction. A major component of the cartilage extracellular matrix is aggrecan, a proteoglycan that imparts compressive resistance to the tissue. Aggrecanase-mediated aggrecan degradation is a significant event in early stage OA. The relative contribution of individual ADAMTS-4 and ADAMTS-5 proteinases to cartilage destruction during OA has not been resolved completely. This review reveals that both ADAMTS-4/ADAMTS-5 are responsible for aggrecan degradation in a human model of OA, and is expected to list down the rational strategies which are being focussed for therapeutic intervention in OA. |
| |
Keywords: | Aggrecan Aggrecanase Aggrecanase inhibitors ADAMTS Osteoarthritis |
本文献已被 PubMed 等数据库收录! |
|