|
|||||
|
|
The Role of Astrocytic Glycogen in Supporting the Energetics of Neuronal Activity |
|
| Authors: | Mauro DiNuzzo Silvia Mangia Bruno Maraviglia Federico Giove |
| Affiliation: | 1. MARBILab, Museo storico della fisica e Centro di studi e ricerche “Enrico Fermi”, Rome, Italy 5. Magnetic Resonance for Brain Investigation Laboratory, Fondazione Santa Lucia IRCCS, Via Ardeatina 306, 00179, Rome, Italy 2. Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA 3. Dipartimento di Fisica, Sapienza Università di Roma, Rome, Italy 4. Fondazione Santa Lucia IRCCS, Rome, Italy |
| Abstract: | Energy homeostasis in the brain is maintained by oxidative metabolism of glucose, primarily to fulfil the energy demand associated with ionic movements in neurons and astrocytes. In this contribution we review the experimental evidence that grounds a specific role of glycogen metabolism in supporting the functional energetic needs of astrocytes during the removal of extracellular potassium. Based on theoretical considerations, we further discuss the hypothesis that the mobilization of glycogen in astrocytes serves the purpose to enhance the availability of glucose for neuronal glycolytic and oxidative metabolism at the onset of stimulation. Finally, we provide an evolutionary perspective for explaining the selection of glycogen as carbohydrate reserve in the energy-sensing machinery of cell metabolism. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |