Current status and future prospects of array-based comparative genomic hybridisation. |
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Authors: | Antoine M Snijders Daniel Pinkel Donna G Albertson |
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Institution: | University of California Comprehensive Cancer Center, USA. |
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Abstract: | The majority of human cancers as well as many developmental abnormalities harbour chromosomal imbalances, many of which result in the gain and/or loss of genomic material. Conventional comparative genomic hybridisation (CGH) has been used extensively to map DNA copy number changes to chromosomal positions. The introduction of microarray CGH provided a powerful tool to precisely detect and quantify genomic aberrations and map these directly onto the sequence of the human genome. In the past several years, a number of different approaches towards array-based CGH have been undertaken. This paper reviews these approaches and presents some of the recently-developed applications of this new technology in both research and clinical settings. |
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Keywords: | comparative genomic hybridisation array CGH microarray DNA copy number cancer chromosomal imbalance developmental abnormality |
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