Synthesis and characterization of a photoresponsive doxorubicin/combretastatin A4 hybrid prodrug |
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Authors: | Wei Liu Li Liang Lifeng Zhao Huan Tan Jie Wu Qihui Qin Xiaojun Gou Xiaohua Sun |
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Institution: | 1. Department of Pharmacy, College of Pharmacy and Biological Engineering, Chengdu University, Chengdu 610106, PR China;2. Laboratory of Antiinfectives, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, PR China |
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Abstract: | To explore the application of photoremovable protecting groups (PPGs) in the field of combination chemotherapy, we designed and synthesized a photoresponsive hybrid prodrug 4 that bearing both doxorubicin (DOX) and combretastatin A4 (CA4). Light triggered drug release investigation found that DOX release was mainly accomplished by 405?nm light while CA4 release was mainly triggered by 365?nm light, i.e., prodrug 4 exhibited a quasi-sequential release behavior when a sequential light irradiation strategy was applied. Cell viability evaluation confirmed the increased cytotoxicity of prodrug 4 compared with individual drugs towards MDA-MB-231cells, indicating that a synergistic effect was achieved. |
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Keywords: | SJZMGVIOTHZLQB-SEYXRHQNSA-N ADHSQCLVTUGLJW-UHFFFAOYSA-N AEHYLDRZROTHEP-UHFFFAOYSA-N SWPSUFGZGLTYCZ-FPLPWBNLSA-N Photoresponsive Hybrid prodrug Doxorubicin Combretastatin Combination chemotherapy |
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