Antigen presentation: TAP dances with ATP. |
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| Authors: | J T Karttunen J Trowsdale P J Lehner |
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| Institution: | Department of Immunology, Wellcome Trust/MRC building, Addenbrookes Hospital, Hills Road, Cambridge, CB2 2XY, UK. |
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| Abstract: | Assembly of antigen-presenting complexes between class I MHC molecules and peptide requires formation of a complex between the 'ABC' peptide transporter, TAP, and newly synthesized class I molecules. Recent studies have provided new insights into the role of ATP in peptide binding, transport and release. |
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