Solid-phase synthesis of positively charged deoxynucleic guanidine (DNG) oligonucleotide mixed sequences |
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Authors: | Reddy Putta Mallikarjuna Bruice Thomas C |
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Institution: | Department of Chemistry and Biochemistry, University of California at Santa Barbara, CA 93106, USA. |
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Abstract: | Positively charged DNG oligonucleotide mixed sequences containing A/T bases were prepared by solid-phase synthesis. Synthesis proceeds in 3'-->5' direction and involves coupling of 3'-Fmoc protected thiourea in the presence of HgCl(2)/TEA with the corresponding 5'-amine of the growing oligo chain. DNG binding characteristics with complementary DNA and with itself have been evaluated. |
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