Study of thermoregulatory activity of a fragment of natural dermorphin precursor Arg-Dermorphin and its analogs |
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Authors: | T. G. Emel’yanova L. S. Guzevatykh N. N. Goryacheva L. A. Andreeva L. Yu. Alfeeva N. F. Myasoedov |
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Affiliation: | (1) Semenov Institute of Chemical Physics, Russian Academy of Sciences, ul. Kosygina 4, 119991 Moscow, Russia;(2) Institute of Molecular Genetics, Russian Academy of Sciences, pl. Kurchatova 46, 123182 Moscow, Russia |
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Abstract: | We studied the effect of a fragment of natural dermorphin (DM) precursor Arg-DM and its analogs (Pro-DM, 4Amino-Pro-DM, Met-DM, Kre-DM, Arg-[DArg2]-DM, and Arg-[DAla4]-DM) after intraperitoneal administration on the functional status of the thermoregulation system in rats. The obtained data demonstrated that the hypothermic and vasomotor effects of Arg-DM were temperature-dependent and had the same pattern as DM (Emelyanova et al., 1996). At termoneutral and room temperatures, the peptide induced a two-phase vascular response. The first phase, vasodilation, was twice as strong as for DM and was not removed by naloxone preadministration. The second phase, vasoconstriction, was blocked by naloxone. Replacement of Arg with 4Amino-Pro, Met, and Kre as well as DAla2 to DArg2 or Gly4 to DAla4 replacements in the Arg-DM molecule affected the thermoregulatory activity of the peptide. For instance, only the vasodilatory response was observed for Arg-[DAla2]-DM and Arg-[DAla4]-DM while only the vasoconstrictive response was observed for 4Amino-Pro-DM.Translated from Izvestiya Akademii Nauk, Seriya Biologicheskaya, No. 1, 2005, pp. 47–54.Original Russian Text Copyright © 2005 by Emelyanova, Guzevatykh, Goryacheva, Andreeva, Alfeeva, Myasoedov. |
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