特异性miRNA调节机理研究进展

MicroRNA(miRNA)是一类新鉴定的非蛋白质编码小RNA，它们在多种生物学过程中发挥重要作用。最新研究表明许多miRNA表达受RNA编辑、差别加工和组织特异性增强子调节而呈现时间和空间特异性，而且基于miRNA调节设计分子药物的前景很好。深入理解miRNA调节的机理有助于揭示一些疾病的发病机理，发现干预治疗的新分子靶标，以及最终建立有效的基因疗法。因此，本文将对miRNA调节机理的最新研究进行综述。

Progress in the Regulative Mechanism of Specific MiRNA

MicroRNAs (miRNAs) are a newly identified class of non-protein-coding small RNAs that play important roles in multiple biological processes. Recent evidence indicates that the expression of many miRNAs is both temporally and spatially regulated by RNA editing, differential processing and tissue-specific enhancers, and the potential for ultimately designing molecular medicines based on the modulation of miRNAs seems good. A better understanding of the mechanism which regulates miRNAs is very helpful to reveal the pathogenesis of some diseases, discover novel molecular targets for treatment by interference, and even develope an effective gene therapy. Therefore, the latest progress in the mechanism regulating miRNAs is summarized in the paper.