Mu-Opioid Receptor in the Nucleus Submedius: Involvement in Opioid-Induced Inhibition of Mirror-Image Allodynia in a Rat Model of Neuropathic Pain |
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| Authors: | Jun-Yang Wang Mei Zhao Fen-Sheng Huang Jing-Shi Tang Yu-Kang Yuan |
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| Institution: | (1) Department of Immunology and Pathogenic Biology, Xi’an Jiaotong University School of Medicine, Xi’an, Shaanxi, 710061, People’s Republic of China;(2) Department of Physiology and Pathophysiology, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi’an Jiaotong University School of Medicine, Xi’an, Shaanxi, 710061, People’s Republic of China |
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| Abstract: | The current study investigated the roles of various subtypes of opioid receptors expressed in the thalamic nucleus submedius
(Sm) in inhibition of mirror-image allodynia induced by L5/L6 spinal nerve ligation in rats. Morphine was microinjected into
the Sm, which produced a dose-dependent inhibition of mirror-image allodynia; this effect was antagonized by pretreatment
with non-selective opioid receptor antagonist naloxone. Microinjections of endomorphin-1 (μ-receptor agonist), or d-Ala2, d-Leu5]-enkephalin (DADLE, δ-/μ-receptor agonist), also inhibited mirror-image allodynia, and these effects were blocked by the
selective μ-receptor antagonist, β-funaltrexamine hydrochloride. The DADLE-induced inhibition, however, was not influenced
by the δ-receptor antagonist naltrindole. The κ-receptor agonist, spiradoline mesylate salt, failed to alter the mirror-image
allodynia. These results suggest that Sm opioid receptor signaling is involved in inhibition of mirror-image allodynia; this
effect is mediated by μ- (but not δ- and κ-) opioid receptors in the rat model of neuropathic pain.
Special issue article in honor of Dr. Ji-Sheng Han. |
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| Keywords: | Mirror-image allodynia Neuropathic pain Thalamic nucleus submedius Opioid Opioid receptor Rat |
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