| 促性腺激素释放激素受体及其基因表达调控 |
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| 作者姓名： | Han XB Cao YQ Zhuang LZ |
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| 作者单位： | 中国科学院动物研究所计划生育生殖生物学国家重点实验室 |
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| 摘 要： | 促性腺激素释放激素（ＧｎＲＨ,ＬＨＲＨ）在体内的重要功能是由ＧｎＲＨ受体介导的。ＧｎＲＨ受体是近年神经分内分泌和生殖生物学研究的热点之一,本文从ＧｎＲＨ受体的分子结构,ＧｎＲＨ受体基因表达调控,ＧｎＲＨ受体分布及表达,调节ＲｎＲＨ受体的因素以及ＧｎＲＨ受体介导的细胞信号转导等几个方面对ＧｎＲＨ受体近年来的研究进展进行了综述,对ＧｎＲＨ受体的研究,将有助于人们进一步了解ＧｎＲＨ受体在生殖调节和恶性肿
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| 关 键 词： | 受体 GnRH受体 垂体αT3－1细胞 基因表达调控 |
GnRH receptor and the regulation of its gene expression |
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| Han XB,Cao YQ,Zhuang LZ.GnRH receptor and the regulation of its gene expression[J].Progress in Physiological Sciences,1998,29(3):198-202. |
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| Authors: | Han X B Cao Y Q Zhuang L Z |
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| Institution: | State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080. |
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| Abstract: | The function of GnRH(gonadotropin-releasing hormone, LHRH) is mediated by GnRH receptor (GnRHR). The study on GnRHR is one of the highlights in neuroendocrinology and reproductive biology. The latest study of GnRHR, including molecular structure of GnRHR, regulation of GnRHR gene expression, distribution of GnRHR, the regulation of GnRHR by peptide and steroid hormone, as well as signal transduction mediated by GnRHR, are reviewed in the present article. Studies on GnRHR will make great contribution to the understanding of the regulation of reproduction and its action for therapy of malignant tumor. |
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