Antigen presentation: peptides and proteins scramble for the exit |
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| Authors: | Lehner P J Hewitt E W Römisch K |
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| Affiliation: | Division of Immunology, Wellcome Trust Centre for Molecular Mechanisms In Disease, CIMR, Addenbrooke's Hospital, Hills Road, CB2 2XY, Cambridge, UK. pjl30@cam.ac.uk |
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| Abstract: | The fate of peptides that fail to bind to major histocompatibility complex class I molecules in the endoplasmic reticulum (ER)has remained unclear. A recent study has revealed that these peptides exit the ER via the Sec61 channel and compete for this pathway with misfolded proteins. |
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