| 发酵生产辅酶Q10高产菌株的选育 |
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| 引用本文： | 陈金卿.发酵生产辅酶Q10高产菌株的选育[J].氨基酸和生物资源,2016,38(1):53-57. |
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| 作者姓名： | 陈金卿 |
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| 作者单位： | 福建省厦门金达威集团股份有限公司,福建厦门,361022 |
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| 摘 要： | 以实验室保存的类球红细菌(Rhodobacter sphaeroides)JDW61为出发菌株,考察了紫外、紫外结合氯化锂和亚硝基胍对菌株产生辅酶Q10能力的诱变效应,并结合辅酶Q10的合成途径设计了快速筛选辅酶Q10高产菌株的模型,获得一株辅酶Q10产量提高的突变株CP222,该菌株摇瓶发酵的辅酶Q10产量为276.14mg·L-1,较出发菌株提高了190%,并且遗传性能稳定。
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| 关 键 词： | 辅酶Q10 类球红细菌 突变株 |
Breeding of Coenzyme Q10 High Yield Strain |
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| Institution: | ,Xiamen Kingdomway Group Company |
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| Abstract: | Rhodobacter sphaeroides JDW61 was used as a starting strain and treated with ultraviolet irradiation,LiCl and nitrosoguanidine for coenzyme Q10 high yield strain.A mutant CP222 was obtained,and its coenzyme Q10 yield was 276.14mg·L~(-1),which was 190% higher than that of the parent strains.The new strain has great potential for the production of coenzyme Q10 and has stable genetic traits. |
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| Keywords: | coenzyme Q10 Rhodobacter sphaeroides mutant |
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