The effect of lead on DNA repair in thymocytes of gamma-irradiated mice |
| |
| Authors: | Medvedev A I Chernikov A V Kublik L N Revina G I |
| |
| Affiliation: | Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia. |
| |
| Abstract: | The effects of Pb on the repair of DNA have been studied in the thymocytes of gamma-irradiated mice exposed to diacetate lead in the drinking water (up to 20 mg/l) for 14-50 days. It is found that lead causes no DNA degradation by itself and renders its genotoxic action indirectly, via inhibiting the repair of single-strand DNA breaks induced by acute gamma-irradiation of mice. Genotoxic effect of lead is reversible that becomes evident when exposed animals are maintained on Pb-free drinking water for 1-2 weeks. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
