血管活性药物对冷暴露实验动物肢端皮肤温度的调节作用

目的:在冷暴露实验动物模型上,评价盐酸哌唑嗪(Pra)和消旋山莨菪碱(Ani)对大鼠、小鼠肢端皮肤温度的调节作用。方法:将80只大鼠随机分为8组,室温下灌胃给药,60 min后放入指定温度(5℃、18℃)环境中冷暴露,并于给药后180 min和300 min使用红外摄像仪测定实验动物尾部近心端1/3处的皮肤温度,观察皮肤温度的变化,评价药效。结果:单独使用Pra对大鼠肢端皮肤温度无影响,对小鼠肢端皮肤温度提高效果较差;而单独使用Ani对大鼠和小鼠肢端皮肤温度均无提高作用;两药联用后实验动物尾温得到显著提高,且具有一定剂量依赖性。结论:Pra和Ani联用能有效提高冷暴露大鼠、小鼠的肢端皮肤温度,并且不会降低体心温度。

Regulative effects of vessel active drugs experimental animals on extremital skin temperature of exposed to cold

Objective： Using an experimental model of animals exposed to cold to evaluate the regulative effects of prazosin hydrcchloride （Pro） and racanisedamine （Ani） on extremital skin temperature of rats and mice. Methods： Eighty animals were randomly divided into eight groups according to the drug dosage. After been administered with drugs by intragastric at room temperature for 60 min, the animals were moved into specified temperature （5℃ ,18℃ ） environment and the skin temperatures at the 1/3 site at the proximal end of tail were measured by infrared camera on 180 min and 300 rain. Effects of drug were evaluated by changes in tail skin temperatures. Results： Pra and Ani combi- nation raised the extremital skin temperattrre of experimental animals significantly in a dose-dependent manner, while single use of Pra was not potent to rots and less potent to mice, and single use of Ani could not raise extremital skin temperature of both rats and mice. Change of rectal tompemture in mice showed that Pra and Ani combination did not affect core temperature. Conclusion： Pra and Ani combination could signifi- cantly raise extremital skin temperature of rats and mice exposed to cold, and would not affect their core （rectal） temperature.