Synthesis and antiproliferative activity of epoxy and bromo compounds derived from estrone |
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| Authors: | Milic D R Kop T Juranic Z Gasic M J Solaja B A |
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| Affiliation: | Faculty of Chemistry, University of Belgrade, Studentski trg 16, PO Box 158, YU-11001, Belgrade, Yugoslavia. |
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| Abstract: | Based on biological properties of epoxyquinols from natural sources, bromo and epoxyquinols derived from estrone were synthesized and screened against Fem-X, HeLa and K(562) cell lines. Evidence was found that the bromine atom and the epoxy moiety significantly increase the antiproliferative activity within the series. |
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