| 旱生香茶菜二萜化合物细胞毒活性的三维构效研究 |
| |
| 引用本文： | 易平,邱明华,孙汉董. 旱生香茶菜二萜化合物细胞毒活性的三维构效研究[J]. 云南植物研究, 2006, 28(1): 95-99 |
| |
| 作者姓名： | 易平 邱明华 孙汉董 |
| |
| 作者单位： | 1. 中国科学院昆明植物研究所,云南,昆明,650204;中国科学院研究生院,北京,100039
2. 中国科学院昆明植物研究所,云南,昆明,650204 |
| |
| 基金项目： | 云南省自然科学基金;国家重点实验室基金 |
| |
| 摘 要： | 应用比较分子力场法（COMFA）研究了一系列旱生香茶菜二萜化合物对人红细胞白血病（K562）、人旱幼粒白血病（HL-60）、人胃腺癌（MKN-28）和人结肠癌（HCT）细胞体外抗肿瘤活性进行了三维定量构效关系的初步研究，其结果将为香条菜二萜的结构修饰和简化，先导化合物的发现提供理论依据。
|
| 关 键 词： | 旱生香茶菜 对映-贝壳杉烯型二萜 细胞毒活性 三维定量构效关系 比较分子力场法 |
| 文章编号： | 0253-2700（2006）01-095-05 |
| 收稿时间： | 2005-06-02 |
| 修稿时间： | 2005-07-13 |
3D QSAR Studies on Cytotoxin Actives of Ent-kauranoids from Isodon xerophilus (Labiatae) by CoMFA |
| |
| YI Ping,QIU Ming-Hua,SUN Han-Dong. 3D QSAR Studies on Cytotoxin Actives of Ent-kauranoids from Isodon xerophilus (Labiatae) by CoMFA[J]. Acta Botanica Yunnanica, 2006, 28(1): 95-99 |
| |
| Authors: | YI Ping QIU Ming-Hua SUN Han-Dong |
| |
| Affiliation: | 1 Laboratory of Phytochemistry, Kunming Institute of Botnny, Chinese Academy of Sciences, Kunming 650204, China; 2 Graduate School of the Chinese Academy o fSciences, Beijing 100039, China |
| |
| Abstract: | It is our aim to establish the CoMFA models of the ent-kauranoids from Isodon xerophilus and guide the design for new anti-cancer drugs.The advanced 3D-QSAR (quantitative structure-activity relationship) method CoMFA (comparative molecular field analysis) was used to study the QSAR relationship of ent-kauranoids with cytotoxicity activity in vitro and led to four CoMFA models.The results of CoMFA models reveal the 3D-relationship between bioactivities and structures of these ent-kauranoids,and will be helpful to further design and find new drugs for higher anti-cancer activities. |
| |
| Keywords: | Isodonxerophilus Ent-kaurenoids Cytotoxicity 3D-QSAR CoMFA |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
