Hyaluronic acid is an endogenous inducer of interleukin-1 production by human monocytes and rabbit macrophages |
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| Authors: | D Hiro A Ito K Matsuta Y Mori |
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| Institution: | 1. National University Heart Centre Singapore, Singapore;2. School of Medicine, University of Auckland, New Zealand;3. Yong Loo Lin School of Medicine, National University of Singapore, Singapore;4. Cardiovascular Research Institute, National University Health System Singapore, Singapore;5. Anglo-Chinese School (Independent), Singapore |
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| Abstract: | When human peripheral monocytes and rabbit peritoneal macrophages were incubated with hyaluronic acid, the media were found to contain interleukin-1 (IL-1) activity and to stimulate collagenase production by rabbit fibroblasts. A digestion of hyaluronic acid by testicular hyaluronidase decreased the IL-1 inducing activity. Polymixin B, an inhibitor of endotoxin, did not exert any effect towards the action of hyaluronic acid. Hyaluronic acid also stimulated human polymorphonuclear leucocytes to produce IL-1 like activity. These results indicate that hyaluronic acid is an endogenous IL-1 inducer and may play important roles in the pathological and/or physiological changes of connective tissues. |
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