Bactericidal activity of magainin 2: use of lipopolysaccharide mutants |
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| Authors: | E A Macias F Rana J Blazyk M C Modrzakowski |
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| Affiliation: | Department of Zoological and Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens 45701. |
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| Abstract: | Salmonella typhimurium and a series of rough lipopolysaccharide mutants derived from it were used as target bacteria to examine the antimicrobial capacity of magainin 2. Magainin 2 demonstrated a dose-related bactericidal activity against the smooth parent strain and the series of lipopolysaccharide mutants. The lipopolysaccharide mutant series showed an ordered increase in sensitivity to the magainin 2 as the depth of the rough lesion in the lipopolysaccharide increased. |
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