Thyroid Function Outcomes after Pegylated Interferon-α and Ribavirin Therapy - For Chronic Hepatitis C |
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Institution: | 1. Division of Clinical Chemistry Area Pathology Service, Hunter;2. Division of Immunopathology Area Pathology Service, Hunter;3. Hepatitis C Service, Gastroenterology Department, John Hunter Hospital, Newcastle, New South Wales, Australia.;1. Jazz Pharmaceuticals, Palo Alto, CA, USA;2. Stanford Sleep Medicine Center, Redwood City, CA, USA;3. Neurology and Sleep Medicine Consultants of Houston, Houston, TX, USA;4. University of South Carolina School of Medicine, Columbia, SC, USA;5. SleepMed, Inc., Columbia, SC, USA;6. Medical University of South Carolina, Charleston, SC, USA;7. University of Arkansas for Medical Sciences, Little Rock, AR, USA |
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Abstract: | ObjectiveTo assess the frequency of new thyroid disease, in patients who did not develop thyroid disease during treatment with interferon-a in combination with ribavirin for hepatitis C, during the 6-month period after the end of therapy.MethodsA prospective study was performed in 190 patients who underwent a combination of interferon-a and ribavirin therapy for hepatitis C infection during the 36-month period between 2006 and 2008. Thyroid function tests were performed at the completion of treatment and at 4, 12, and 24 weeks of follow-up.ResultsDuring the 6 months after the completion of interferon-a and ribavirin therapy in the 190 study patients with hepatitis C infection, there were 2 cases of thyroid disease. One patient had the typical biphasic thyroiditis, and the other had primary hypothyroidism. Thus, the prevalence of thyroid disease in this setting was 2 of 190 patients (1.0%).ConclusionThe majority (99%) of patients had normal thyroid outcomes at 6-month follow-up. Only 1 patient had symptoms. This finding is reassuring and eliminates the need for ongoing thyroid surveillance during this time and probably longer. In the absence of symptoms, only a single thyroid-stimulating hormone measurement at 6-month review is recommended. (Endocr Pract. 2010;16:934-939) |
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