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Large Adrenal Oncocytoma with Uncertain Malignant Potential: Case Report and Review of Literature
Affiliation:1. Endocrine Unit, Second Department of Internal Medicine-Propaedeutic, Research Institute and Diabetes Center;2. Second Department of Pathology;3. Third Surgery Department, Athens University, Attikon University Hospital, Athens, Greece;4. Hellenic National Diabetes Center for the Prevention, Research and Treatment of Diabetes and Its Complications, Athens, Greece.;1. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA;2. Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Abstract:ObjectiveTo report a case of oncocytoma, a relatively rare adrenal tumor, which most commonly is detected as an adrenal incidentaloma.MethodsWe present a case report, including laboratory, imaging, and pathologic findings, of a 47-year-old obese woman who had hypertension and an incidentally found large, left adrenal mass.ResultsOn the basis of the hormonal evaluation, this mass was a nonsecreting adrenal tumor, which histologically proved to be an oncocytoma with borderline malignant characteristics. A collective analysis of the few cases of adrenal oncocytoma published in the medical literature showed that our case corresponded to the previously published cases in preponderant location (left side) as well as the general size (11.4 cm in the largest dimension) and weight (372 g).ConclusionAdrenal oncocytoma should be included in the differential diagnosis of adrenal incidentalomas, especially if large tumors are detected. In addition, a longterm follow-up is suggested because there are no certain clues about the true potential of this tumor. (Endocr Pract. 2010;16:641-645)
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