Neural stem cell therapy for brain disease |
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Authors: | Lan Zhao Jian-Wei Liu Hui-Yan Shi Ya-Min Ma |
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Institution: | Lan Zhao, Hui-Yan Shi, Ya-Min Ma, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, ChinaLan Zhao, Hui-Yan Shi, Ya-Min Ma, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, ChinaJian-Wei Liu, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China |
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Abstract: | Brain diseases, including brain tumors, neurodegenerative disorders, cerebrovascular diseases, and traumatic brain injuries, are among the major disorders influencing human health, currently with no effective therapy. Due to the low regeneration capacity of neurons, insufficient secretion of neurotrophic factors, and the aggravation of ischemia and hypoxia after nerve injury, irreversible loss of functional neurons and nerve tissue damage occurs. This damage is difficult to repair and regenerate the central nervous system after injury. Neural stem cells (NSCs) are pluripotent stem cells that only exist in the central nervous system. They have good self-renewal potential and ability to differentiate into neurons, astrocytes, and oligodendrocytes and improve the cellular microenvironment. NSC transplantation approaches have been made for various neurodegenerative disorders based on their regenerative potential. This review summarizes and discusses the characteristics of NSCs, and the advantages and effects of NSCs in the treatment of brain diseases and limitations of NSC transplantation that need to be addressed for the treatment of brain diseases in the future. |
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Keywords: | Neural stem cell Brain disease Therapy Animal experiment Clinical trial Cellular therapy |
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| 点击此处可从《World journal of stem cells》浏览原始摘要信息 |
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