Effects of shear stress on differentiation of stem cells into endothelial cells |
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Authors: | Yan Huang Jia-Yi Qian Hong Cheng Xiao-Ming Li |
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Affiliation: | Yan Huang, Jia-Yi Qian, Hong Cheng, Xiao-Ming Li, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China |
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Abstract: | Stem cell transplantation is an appealing potential therapy for vascular diseases and an indispensable key step in vascular tissue engineering. Substantial effort has been made to differentiate stem cells toward vascular cell phenotypes, including endothelial cells (ECs) and smooth muscle cells. The microenvironment of vascular cells not only contains biochemical factors that influence differentiation but also exerts hemodynamic forces, such as shear stress and cyclic strain. More recently, studies have shown that shear stress can influence the differentiation of stem cells toward ECs. A deep understanding of the responses and underlying mechanisms involved in this process is essential for clinical translation. This review highlights current data supporting the role of shear stress in stem cell differentiation into ECs. Potential mechanisms and signaling cascades for transducing shear stress into a biological signal are proposed. Further study of stem cell responses to shear stress will be necessary to apply stem cells for pharmacological applications and cardiovascular implants in the realm of regenerative medicine. |
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Keywords: | Shear stress Stem cells Cell differentiation Endothelial cells Mechanotransduction |
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| 点击此处可从《World journal of stem cells》浏览原始摘要信息 |
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