Markedly Low Hemoglobin A1c in a Patient with an Unusual Presentation of ß-Thalassemia Minor |
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Institution: | 1. Department of Internal Medicine, St. Joseph Mercy Oakland Hospital, Pontiac, Michigan;2. Division of Endocrinology, Henry-Ford Hospital, Detroit, Michigan;3. Division of Endocrinology, Wayne State University School of Medicine, Detroit, Michigan.;2. Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, USA |
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Abstract: | ObjectiveTo describe very low hemoglobin A1c levels in a patient with type 2 diabetes mellitus and an unusual presentation of β-thalassemia minor.MethodsWe present the clinical and laboratory findings of the study patient.ResultsA 64-year-old African American man with type 2 diabetes mellitus was referred to the endocrinology clinic with a hemoglobin A1c level of 1.6% despite elevated blood glucose concentrations. A red blood cell survival study with chromium-51 revealed that he had a reduced erythrocyte life span less than 25% of normal. He also had a markedly elevated reticulocyte count ranging from 236 to 534 x 103/μL (reference range, 25-75 x 103/μL). The laboratory findings, which are not characteristic of ß-thalassemia minor, could be the cause of the markedly low hemoglobin A1c in this patient.ConclusionsAlthough rare, when associated with marked erythrocyte turnover, β-thalassemia minor can lead to a severe reduction in HbA1c levels. In this scenario, glycemic control is best assessed by measuring fructosamine. (Endocr Pract. 2010;16:89-92) |
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