Allele Distribution at the HVR-IgH Hypervariable Locus in Unrelated Individuals Living in the Urals, Siberia, and Northern Kazakhstan

Allelic polymorphism at a hypervariable locus mapped to the 5"-region of the gene cluster encoding J_H segments of human immunoglobulin heavy chain H (IgH-VNTR) was typed in 462 unrelated individuals living in the Urals, Siberia, and Northern Kazakhstan. Molecular characteristics of the three previously unknown IgH-VNTR alleles are presented. The observed genotype frequencies were concordant with those expected under the Hardy–Weinberg distribution. The data obtained can be used in the work of regional forensic laboratories.