Development of a bioadhesive nanoformulation with Glycyrrhiza glabra L. extract against Candida albicans |
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| Authors: | Luís Roque Noélia Duarte Maria Rosário Bronze Catarina Garcia Julia Alopaeus Jesus Molpeceres |
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| Affiliation: | 1. CBiOS, Universidade Lusófona de Humanidades e Tecnologias, Lisboa, Portugal;2. Department of Biomedical Sciences, Faculty of Pharmacy, University of Alcalá, Alcalá de Henares, Spain;3. iMed.ULisboa-Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal;4. Instituto de Biologia Experimental Tecnológica, Universidade de Lisboa, Oeiras, Portugal;5. School of Pharmacy, University of Oslo, Oslo, Norway;6. Department of Biomedical Sciences, Faculty of Pharmacy, University of Alcalá, Alcalá de Henares, Spain |
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| Abstract: | AbstractGlycyrrhiza glabra L. is considered an important source of bioactive compounds. This study aimed at the development of an efficient solution for the treatment of oral candidiasis. Several extracts of Glycyrrhiza glabra L. were prepared using different solvents and their potential in vitro antifungal activity was assessed. Ethanolic extracts showed the most promising results against C. albicans. This extract was incorporated into mucoadhesive nanoparticles (PLA, PLGA and alginate), which were further included in an oral gel, an oral film and a toothpaste, respectively. The results showed that nanoparticles were successfully produced, presenting a mean size among 100–900?nm with high encapsulation efficiency. In vitro studies showed that the most bioadhesive formulation was the oral film with extract-loaded PLGA nanoparticles, followed by the toothpaste with extract-loaded alginate nanoparticles and the oral gel with extract-loaded PLA nanoparticles. |
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| Keywords: | Antifungal glabridin Glycyrrhiza glabra L. nanoparticles bioadhesion |
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