Antibacterial and antilarval activity of deep-sea bacteria from sediments of the West Pacific Ocean |
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| Authors: | Ying Xu Li Miao Xian-Cui Li Xiang Xiao |
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| Affiliation: | 1. Department of Biology/Coastal Marine Laboratory , Hong Kong University of Science and Technology (HKUST), Clear Water Bay , Kowloon, Hong Kong;2. The Third Institute of Oceanography, State Oceanic Administration , Xiamen, PR China |
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| Abstract: | Abstract Deep-sea microorganisms are a new source of bioactive compounds. In this study, crude ethyl acetate extracts of 176 strains of deep-sea bacteria, isolated from sediments of the West Pacific Ocean, were screened for their antibacterial activity against four test bacterial strains isolated from marine biofilms. Of these, 28 deep-sea bacterial strains exhibited antibacterial activity against one or more of the bacteria tested. Active deep-sea bacterial strains belonged mainly to the genera of Pseudomonas, Psychrobacter and Halomonas. Additionally, antilarval activity of 56 deep-sea bacterial strains was screened using Balanus amphitrite larvae. Seven bacterial strains produced metabolites that had strong inhibitive effects on larval settlement. None of these metabolites showed significant toxicity. The crude extract of one deep-sea Streptomyces strain could completely inhibit larval settlement at a concentration of 25 μg ml?1. |
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| Keywords: | Deep-sea bacteria antibacterial activity antilarval activity |
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