|
|||||
|
|
Improved antibacterial activities of coumarin antibiotics bearing 5',5'-dialkylnoviose: biological activity of RU79115 |
|
| Authors: | Musicki B Periers A M Laurin P Ferroud D Benedetti Y Lachaud S Chatreaux F Haesslein J L Iltis A Pierre C Khider J Tessot N Airault M Demassey J Dupuis-Hamelin C Lassaigne P Bonnefoy A Vicat P Klich M |
| Institution: | Medicinal Chemistry, Hoechst Marion Roussel/Aventis, Romainville, France. branislav.musicki@aventis.com |
| Abstract: | A new series of coumarin inhibitors of DNA gyrase B bearing a N-propargyloxycarbamate at C-3' of various 5',5'-dialkylnoviose, including RU79115, were synthesised and their antibacterial activities have been delineated. Introduction of dialkyl substituents at 5'5'-position of noviose leads to coumarin analogues with improved in vitro and in vivo antibacterial activity. |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ | |