Design and synthesis of bicyclic pyrimidinone-based HCV NS3 protease inhibitors |
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| Authors: | Glunz Peter W Douty Brent D Decicco Carl P |
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| Institution: | Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ 08543-5400, USA. peter.glunz@bms.com |
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| Abstract: | A series of bicyclic pyrimidinone-based HCV NS3 protease inhibitors was synthesized via selective C8 position functionalization. Substituted phenylamides and phenylureas were preferred in the S2 binding pocket. |
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