A Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replication |
| |
| Authors: | Pedro Jares M Gloria Luciani J Julian Blow |
| |
| Institution: | (1) Wellcome Trust Biocentre, University of Dundee, Dundee, DD1 5EH, UK;(2) Genomics Unit, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain |
| |
| Abstract: | Background Early in the cell cycle a pre-replicative complex (pre-RC) is assembled at each replication origin. This process involves
the sequential assembly of the Origin Recognition Complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins
onto chromatin to license the origin for use in the subsequent S phase. Licensed origins must then be activated by S phase-inducing
cyclin-dependent kinases (S-CDKs) and the Dbf4/Cdc7 kinase. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
