The planetary biology of cytochrome P450 aromatases |
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| Authors: | Eric A Gaucher Logan G Graddy Tang Li Rosalia CM Simmen Frank A Simmen David R Schreiber David A Liberles Christine M Janis Steven A Benner |
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| Affiliation: | (1) Foundation for Applied Molecular Evolution, 1115 NW 4th Street, Gainesville, FL 32601-4256, USA;(2) Department of Psychiatry, Duke University Medical Center, Durham, NC 27708, USA;(3) Department of Physiology & Biophysics, Medical Sciences & Children's Nutrition Center, University of Arkansas, 1120 Marshall Street, Little Rock, AR 72202, USA;(4) Computational Biology Unit, Bergen Center for Computational Science, University of Bergen, 5020 Bergen, Norway;(5) Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA;(6) Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA |
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| Abstract: | Background Joining a model for the molecular evolution of a protein family to the paleontological and geological records (geobiology), and then to the chemical structures of substrates, products, and protein folds, is emerging as a broad strategy for generating hypotheses concerning function in a post-genomic world. This strategy expands systems biology to a planetary context, necessary for a notion of fitness to underlie (as it must) any discussion of function within a biomolecular system. |
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