Synthesis and antinephritic activities of quinoline-3-carboxamides and related compounds. |
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| Authors: | Kiyoshi Tsuji Glen W Spears Katsuya Nakamura Takashi Tojo Nobuo Seki Aiko Sugiyama Masaaki Matsuo |
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| Affiliation: | Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd, 1-6, Kashima 2-chome,Yodogawa-ku, 532-8514, Osaka, Japan. kiyoshi_tsuji@po.fujisawa.co.jp |
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| Abstract: | A series of linomide-related quinoline-3-carboxamides and their analogues was prepared and evaluated for antinephritic activities. The 6-MeS derivative 7a was highly effective in two nephritis models, namely chronic graft-versus-host disease and autoimmune MRL/l mice. |
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