Discovery of diacylphloroglucinols as a new class of GPR40 (FFAR1) agonists |
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| Authors: | Bharate Sandip B Rodge Atish Joshi Rajendra K Kaur Jaspreet Srinivasan Shaila Kumar S Senthil Kulkarni-Almeida Asha Balachandran Sarala Balakrishnan Arun Vishwakarma Ram A |
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| Institution: | Department of Medicinal Chemistry, Piramal Life Sciences Limited, 1 Nirlon Complex, Off Western Express Highway, Goregaon (E), Mumbai 400063, India. |
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| Abstract: | In this letter, we report discovery of diacylphloroglucinol compounds as a new class of GPR40 (FFAR1) agonists. Several diacylphloroglucinols with varying length of acyl functionality and substitution on aromatic hydroxyls were synthesized and evaluated for GPR40 agonism using functional calcium-flux assay. Out of 17 compounds evaluated, 14, 17, 19 and 25 exhibited good GPR40 agonistic activity with EC(50) values ranging from 0.07 to 8 microM (pEC(50) 7.12-5.09), respectively, with maximal agonistic response of 84-102%. |
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