The fumarate reductase system as a site of anthelmintic attack inAscaris suum |
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| Authors: | Margaret M Barrowman Susan E Marriner James A Bogan |
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| Institution: | (1) Department of Veterinary Pharmacology, University of Glasgow Veterinary School, Bearsden Road, Bearsden, G61 1QH Glasgow, UK;(2) Present address: Department of Experimental Pathology, School of Medicine, University College London, WC1E 6JJ London, UK |
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| Abstract: | Various benzimidazole compounds have been shown to be highly eIIective as inhibitors (up to 50% reduction of activity) in vitro of the helminth-specilic enzyme, fumarate reductase, ofAscaris suum. Anthelmintically active and inactive benzimidazoles were similarly effective as inhibitors of enzyme activity. Albendazole-induced inhibition of Iumarate reductase was not observed when the enzyme was preincubated with NADH. |
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