Pharmacological evidence for the involvement of the cAMP cascade in sensory fatigue in Drosophila |
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Authors: | Gabriel Corfas Yadin Dudai |
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Institution: | (1) Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel;(2) Present address: Dept. of Neurobiology, Harvard Medical School, 02115 Boston, MA, USA |
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Abstract: | Summary We have investigated the effect of systemic treatment with drugs that affect the cAMP cascade on the sensory response and sensory fatigue in an identified mechanosensory neuron of Drosophila. Forskolin, an activator of adenylate cyclase, decreases the sensory response of the neuron. H7, an inhibitor of protein kinase, inhibits sensory fatigue. Octopaminergic ligands facilitate sensory fatigue. These results, together with our previous neurogenetic analysis of sensory fatigue in Drosophila (Corfas and Dudai 1990), corroborate the hypothesis that the cAMP cascade is involved in the generation and modulation of sensory fatigue.Abbreviations
ANP
antero-notopleural (neuron)
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CDMF
chlordimeform
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ISI
interstimulus interval |
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Keywords: | Mechanosensory neuron Sensory fatigue cAMP cascade Drosophila Memory mutants |
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