Effects of cholinergic and adrenergic agonists on the secretion of fluid and protein by submandibular glands of the guinea-pig and the mouse |
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| Institution: | 1. Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China;2. Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China;3. Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China;4. Department of Pathology and Physiology, Peking University Health Science Center, Beijing 10038, PR China;5. Department of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington, 850 Republican Street N121, Seattle, WA 98109, USA |
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| Abstract: | Significant differences were observed between the guinea-pig and the mouse in terms of the secretion of fluid, protein and secretory granules from submandibular glands in response to pilocarpine, phenylephrine and isoproterenol. In both the guinea-pig and the mouse, the secretory responses induced by pilocarpine, phenylephrine and isoproterenol were inhibited by pretreatment with 4-DAMP, phentolamine and propranolol, respectively. The results suggest that the submandibular glands of the guinea-pig and the mouse have M3-cholinoreceptors, as well as α- and β-adrenoceptors, and that these receptors play different roles in the secretion of fluid, protein and secretory granules from guinea-pig and mouse submandibular glands. |
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