N-Oxidation of Quinoline and Isoquinoline by Cunninghamella elegans |
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| Affiliation: | 1. Dipartimento di Chimica & Centro Interdipartimentale SMART, Università degli Studi di Bari Aldo Moro, Campus Universitario, Via E. Orabona, 4, 70125 Bari, Italy;2. Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute, Università degli Studi di Messina, viale Annunziata, 98168 Messina, Italy;1. Biosciences Center, National Renewable Energy Laboratory, Golden, CO 80401, USA;2. Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN, USA;3. Department of Biological Science, Purdue University, West Lafayette, IN, USA;4. Department of Plant Science and Landscape Architecture, University of Maryland, College Park, MD 20742, USA;5. Department of Cellular and Molecular Biosciences, University of Maryland, College Park, MD 20742, USA;6. Department of Plant Biology, Michigan State University, East Lansing, MI 48824, USA;7. National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, USA;1. Department of Plant Physiology and Biochemistry, Faculty of Biology and Environmental Protection, University of Łódź, Banacha 12/16, 90-237, Łódź, Poland;2. Department of Environmental Chemistry, Faculty of Chemistry, University of Łódź, Pomorska 163, 90-236, Łódź, Poland;3. Institute of Plant Physiology, Polish Academy of Science, Niezapominajek 21, 30-239, Kraków, Poland;4. Department of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Łódź, Banacha 12/16, 90-237, Łódź, Poland |
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| Abstract: | Sutherland, J. B., Freeman, J. P., Williams, A. J., and Cerniglia, C. E. 1994. N-oxidation of quinoline and isoquinoline by Cunninghamella elegans. Experimental Mycology 18: 271-274. Cultures of Cunninghamella elegans were grown for 7 days in liquid Sabouraud medium containing 1.9mM quinoline or isoquinoline. The spent culture media were extracted with ethyl acetate; metabolites were purified by high-performance liquid chromatography (HPLC) and thin-layer chromatography. The major metabolite produced from each compound was identified by the HPLC elution time, ultraviolet/visible absorption spectrum, and mass spectrum. Under similar conditions, approximately 65% of the added quinoline and 3% of the added isoquinoline were metabolized to quinoline N-oxide and isoquinoline N -oxide, respectively. |
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