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Integrative multi-omics analysis reveals the critical role of the PBXIP1 gene in Alzheimer's disease
Authors:Jingyun Zhang  Xiaoyi Sun  Xueqing Jia  Binggui Sun  Shijun Xu  Weiping Zhang  Zuyun Liu
Affiliation:1. Center for Clinical Big Data and Analytics of the Second Affiliated Hospital, and Department of Big Data in Health Science School of Public Health, the Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China;2. Department of Neurobiology, School of Basic Medical Sciences, Key Laboratory of Medical Neurobiology (Ministry of Health of China), Key Laboratory of Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China;3. Institute of Material Medica Integration and Transformation for Brain Disorders, and School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China;4. Department of Pharmacology, Institute of Neuroscience, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang Province Key Laboratory of Mental Disorder's Management, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Abstract:
Keywords:aging  Alzheimer's disease  DNA methylation clocks  neuropathology  proteomics  RNA-seq
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