Glutathione concentrations in the hard clam,Mercenaria mercenaria,following laboratory exposure to lead (a potential model system for evaluating exposure to carcinogens and toxins) |
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| Affiliation: | 1. South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, PR China;2. Environment and Plant Protection Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China;3. Horticultural Sciences Department, PO Box 110690, IFAS, University of Florida, Gainesville, FL 32611-0690, USA;1. Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China;2. The New Zealand Institute for Plant and Food Research Limited, Food Industry Science Centre, Private Bag 11600, Palmerston North 4442, New Zealand |
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| Abstract: | This study determined whether M. mercenaria retain Pb from sea water and whether endogenous GSH acts as an important primary response modulator of heavy metal detoxification. Lead accumulation in M. mercenaria may be related to the rate of endogenous formation of GSH. Glutathione concentrations decrease with increasing early exposure to Pb and increase after continued acute exposure. M. mercenaria do not accumulate Pb but appear to reach an equilibrium with their environment. GSH formation may protect the hard clam from accumulating excess Pb by forming insoluble sulfide adducts with Pb and excreting these complexes. |
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