The STL1 gene of Saccharomyces cerevisiae is predicted to encode a sugar transporter-like protein |
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| Affiliation: | 1. Pediatrics Department, Souro Sanou Teaching Hospital, Bobo-Dioulasso, Burkina Faso;2. Pediatrics Department, Regional Teaching Hospital of Ouahigouya, Ouahigouya, Burkina Faso;1. Institute of Cell Biology, University of Bern, Switzerland;2. Graduate School for Cellular and Biomedical Sciences at the University of Bern, Switzerland;1. Department of Biology, College of Staten Island, City University of New York, 2800 Victory Blvd, Staten Island, NY 10314, USA;2. PhD Program in Biology, The Graduate Center, City University of New York, 365 Fifth Avenue, New York 10016, USA;3. Institute for Macromolecular Assemblies, City University of New York, 160 Convent Avenue, New York, NY 10031, USA |
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| Abstract: | A gene has been cloned from the yeast Saccharomyces cerevisiae which, on the basis of the deduced translation product, encodes a sugar transporter-like protein. This gene, STL1, was identified as an open reading frame (ORF) closely linked to the cinnamic-acid-resistance gene POF1 on chromosome IV. The putative translation product of STL1 (STL1) contains 536 amino acids, with a Mr, of 60 507. Hydropathy analysis of STL1 suggests that it contains the twelve transmembrane (TM) domains characteristic of a family of sugar transporters from S. cerevisiae and other organisms. STL1 displays greatest homology (28% identity) to the products of the yeast HXT2 (hexose transporter) and GAL2 (galactose transporter) genes. Disruption of STL1 had no detectable effect on yeast growth on glucose, galactose, mannose, maltose or glycerol as sole carbon source. The transport function of the gene product remains unknown at present. |
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