Discovery of a nuclease-resistant, non-natural dinucleotide that inhibits HIV-1 integrase |
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Authors: | Taktakishvili M Neamati N Pommier Y Nair V |
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Affiliation: | Department of Chemistry, The University of Iowa, Iowa City, IA 52242, USA. |
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Abstract: | Integration of HIV viral DNA into human chromosomal DNA catalyzed by HIV integrase is essential for the replication of HIV. Discovery of novel inhibitors of HIV integrase is of considerable significance in approaches to the development of therapeutic agents against AIDS. We have synthesized a new dinucleotide 1 with an internucleotide phosphate bond that is unusually resistant to exonucleases. This compound exhibits potent anti-HIV-1 integrase activity. |
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