Formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine under anaerobic conditions by reductively activated nitro 5-deazaflavin derivatives. |
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| Authors: | Y Mikata M Kishigami M Nishida S Yano T Kawamoto Y Ikeuchi F Yoneda |
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| Affiliation: | Department of Chemistry, Faculty of Science, Nara Women's University, Japan. |
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| Abstract: | Electrolytically reduced 6- and 8-nitro-5-deazaflavin derivatives have been found to interact to react specifically with guanine base by means of cyclic voltammetry. Electrolytic reductions of 6- and 8-nitro-5-deazaflavin derivatives in the presence of the 2'-deoxyguanosine under anaerobic conditions resulted in prominent formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine. |
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