Low-molecular peptides from tissues of hibernating and cold-adapted animals influence cell proliferation in the Ehrlich ascitic carcinoma

Polypeptides with cytostatic activity are known to be present in animal tissues during winter dormancy. A 1-10 kDa polypeptide fraction with cytostatic activity was obtained from brain tissue of hibernating ground squirrels and cold-adapted Yakut horses. The pattern of cytostatic activity of this fraction towards tumor cells is of great interest. We present results testifying to cytostatic activity of this fraction towards the Ehrlich ascitic carcinoma cells. The cytostatic effect is realized in tumor cells at the genetic level.