Involvement of curli fimbriae in the biofilm formation of Enterobacter cloacae |
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Authors: | Kim Sung-Min Lee Hee-Woo Choi Yeh-Wan Kim Shuk-Ho Lee Je-Chul Lee Yoo-Chul Seol Sung-Yong Cho Dong-Taek Kim Jungmin |
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Institution: | Department of Microbiology, School of Medicine, Kyungpook National University, Daegu, 700-422, Republic of Korea. |
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Abstract: | In this study, we examined the biofilm forming ability, the mRNA expression of curli genes and the morphologies of curli fimbriae
and biofilms in clinical isolates of Enterobacter cloacae. The csgBA operon was found in 11 (78.6%) of the 14 isolates. The ability of E. cloacae isolates to form biofilms was significantly correlated with the mRNA expression level of the csgA and csgD genes. The curli protein fimbriae appeared as tangled fibers and the curli-proficient strain formed mature biofilms. Our
data suggest that the expression of the curli fimbriae play an important role in biofilm formation in E. cloacae. |
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