Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus |
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| Authors: | Sebastian Dolff Wayel H Abdulahad Johanna Westra Berber Doornbos-van der Meer Pieter C Limburg Cees GM Kallenberg Marc Bijl |
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| Institution: | 1.Department of Rheumatology and Clinical Immunology,University Medical Center Groningen, University of Groningen,Groningen,The Netherlands;2.Department of Nephrology,University Hospital Essen, University Duisburg-Essen,Essen,Germany |
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| Abstract: | Introduction Systemic lupus erythematosus (SLE) is an autoimmune disease accompanied by a disturbed T-cell balance skewed towards effector
T-cells, in particular Th17-cells. The novel cytokine interleukin-21 (IL-21) is suggested to be crucial for triggering T-cell
responses towards IL-17 producing cells. Thus, we aimed to investigate the ability of T-cells to produce IL-21 and IL-17 in
SLE patients. |
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| Keywords: | SLE Th17-cells IL-21 T-cells |
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